ࡱ> ]_Z[\ c3bjbj /*    4 7;T!!!:::::::=-@J:! !!!:#:4,4,4,!:4,!:4,4,r5TJ6@}L&I T%5:;07;5w@p%w@66Jw@6!!4,!!!!!::4,!!!7;!!!!w@!!!!!!!!! :  SCIENTIFIC PROGRAM Revised 10/09/09  A Joint Conference of the 14th In Vivo EPR Spectroscopy and Imaging and the 11th International EPR Spin Trapping/Spin Labeling Condado Plaza Hotel, San Juan, Puerto Rico, May 2-6, 2010 WEDNESDAY, MAY 57:30amContinental Breakfast and Poster Viewing8:00amSpin Labeling in Membranes (Chair: W. Karol Subczynski, Medical College of Wisconsin)Physical Properties of Lipid Bilayers using Spin Labeling EPR (W. Karol Subczynski, Medical College of Wisconsin)8:20amElectrostatic Landscape of Membrane Proteins and Transmembrane Dielectric Constant Gradients by EPR of pH-sensitive Nitroxides (Alex Smirnov, North Carolina State University, Raleigh)8:40amDynamics of Antimicrobial Peptide-Membrane Interactions (Jimmy Feix, Medical College of Wisconsin)9:00amDiscussion9:10amIn Vivo Oximetry and Redox Imaging (Chair: Hideo Utsumi, Kyushu University, Fukuoka, Japan)Magnetic Resonance Imaging of Tumor Physiology and Metabolic Profile (Murali Krishna Cherukuri, NCI)9:30amEPR Oximetry: New Probes and Opportunities for Clinical Applications (Periannan Kuppusamy, Ohio State University)9:50amDevelopment of Different Type of Overhauser-MRI and Probes for Animal Models (Hideo Utsumi, Kyushu University, Fukuoka, Japan)10:10amDiscussion10:20amBreak and Poster Viewing10:50amNovel Actions and Reactions of Quinones (Chair: Tadeusz Sarna, Jagiellonian University, Krakow, Poland)Detection and Identification of a Novel Carbon-Centered Quinone Ketoxy Radical during Metal-Independent Decomposition of Hydroperoxides by Halogenated Quinones (Ben-Zhan Zhu, Chinese Academy of ֱapps)11:10amSome Newly Discovered Chemistry of Quinones, Semi-quinones, and Hydroquinones: New Routes to Formation of ROS and Detoxification of PCBs (Garry Buettner, University of Iowa, Iowa City)11:30amRole of Melanin Quinone Groups in the Generation and Scavenging of Reactive Oxygen Species (Tadeusz Sarna, Jagiellonian University, Krakow, Poland)11:50amDiscussion12:00pmLunch12:45pmFree Radicals in Rare Diseases (Chair: Maria Kadiiska, NIEHS)Possible Allergic Reactions to (Bi)sulfite: Initiated Oxidation by EPO (Kalina Ranguelova, NIEHS)1:05pmPeroxidative Metabolism of Beta(2)-agonists Salbutamol and Fenoterol and their Analogues: Mechanisms that affect Control of Bronchospasm and Asthma Exacerbation (Kristof Reszka, University of Cincinnati)1:25pmPossible Involvement of Free Radical Metabolites in the Etiology of Drug-Induced Agranulocytosis (Arno Siraki, University of Alberta)1:45pmDiscussion1:55pmIn Vivo Spin-Trapping by ESR: Lipid-Derived Free Radical Production in Superantigen-induced Interstitial Pneumonia of Immunocompromised Mice (Maria Kadiiska, NIEHS)2:15pmOxidant-Antioxidant Interactions during Trypanosoma Cruzi Invasion to Macrophages: Implications for Chagas Disease (Rafael Radi, Universidad de la Republica, Montevideo, Uruguay)2:35pmIn Vivo Molecular Imaging of Protein Radicals in Rare Diseases (Rheal Towner, Oklahoma Medical Research Foundation)2:55pmDiscussion3:05pmBreak and Poster Viewing3:35pm__________________________ Short Oral Communications (Chair: TBD) ____________________ (_______)3:50pm____________________ (_______)4:05pm____________________ (_______)4:20pm____________________ (_______)4:35pm____________________ (_______)4:50pm____________________ (_______)5:05pmAdjourn6:30pmConference Banquet TUESDAY, MAY 47:30amContinental Breakfast and Poster Viewing8:00amEPR and Spin Trapping in Redox Biology (Chairs: Neil Hogg, Medical College of Wisconsin and Jeannette Vasquez-Vivar, Medical College of Wisconsin)Spin Trapping Studies with Peroxiredoxin-null Yeasts (Ohara Augusto, Instituto de Quimica, Sao Paulo, Brazil)8:20amEPR Tracking of Superoxide in Biological Milieu (Paul Tordo, Universites dAix-Marseille )8:40amThe Challenge and Significance of Free Radical Detection in Biological Systems (Ronald Mason, NIEHS)9:00amDiscussion9:10amTracking Radicals in Biological Polymers...Searching for the Smoking Gun (Michael Davies, Heart Research Institute, Sydney, Australia)9:30amS-Nitrosothiol Formation: Radical and Non-radical Pathways (Neil Hogg, Medical College of Wisconsin)9:50amSuperoxide from NOS Uncoupling (Jeannette Vasquez-Vivar, Medical College of Wisconsin)10:10amDiscussion10:20amBreak and Poster Viewing10:50amEPR Techniques in Metalloproteins (Sandra Eaton, University of Denver)Impact of Mutations on the Iron-sulfur cluster of ETF-QO (Sandra Eaton, University of Denver)11:10amCombining High-field EPR with Site-directed NO Spin Labeling Reveals Unique Information on Protein Structure and Local Micro-environment (Klaus Moebius, Free University Berlin, Germany)11:30amMultifrequency EPR of Cupric Sites: Four Coordinate, Three Coordinate, and Free Radical Like Sites (William Antholine, Medical College of Wisconsin)11:50amRapid-Freeze-Quench EPR: What, Why, and How (Brian Bennett, Medical College of Wisconsin)12:00pmDiscussion12:10pmLunch 12:55pmSpin Trap/Spin Label Synthesis (Chair: Micael Hardy, Universites dAix-Marseille)New Spin Probes for EPR Measurements of pH and ROS (Igor Grigoriev, Novosibirsk Institute of Organic Chemistry, Russia)1:15pmDesign and Development of Spin Traps: Towards Detection of Superoxide in Biological Media (Micael Hardy, Universites dAix-Marseille)1:35pmSynthesis and New Applications of Nitroxides (Joy Joseph, Medical College of Wisconsin)1:55pmMultifunctionalin Vivo EPR using Nitroxyl and TritylRadicals (Valery Khramtsov, Davis Heart & Lung Research Institute)2:15pmDiscussion2:25pm__________________________ Short Oral Communications (Chair: TBD) ____________________ (_______)2:40pm____________________ (_______)2:55pm____________________ (_______)3:10pmBreak and Poster Viewing3:40pm____________________ (_______)3:55pm____________________ (_______)4:10pm____________________ (_______)4:25pm____________________ (_______)4:40pm____________________ (_______)4:55pm____________________ (_______)5:10pm____________________ (_______)5:25pmPoster Viewing and Cash Bar9:30pmAdjourn MONDAY, MAY 37:30amContinental Breakfast and Poster Viewing8:00amWelcome Address (Antonio Alegria)8:10amEPR Instrumentation: the Latest and the Greatest (Chair: Balaraman Kalyanaraman, Medical College of Wisconsin)8:15am Rapid Scan EPR (Gareth Eaton, University of Denver)8:45amFrequency Modulation EPR Spectroscopy from L- to W-band (Wojciech Froncisz, Jagiellonian University, Krakow, Poland)9:15amExperiments at Low Microwave Frequencies (James Hyde, Medical College of Wisconsin)9:45amESR Studies of Dynamics and Structure of Membranes and Proteins at ACERT (Jack Freed, Cornell University)10:15amBreak and Poster Viewing10:45amProtein Structure and Dynamics by Pulsed EPR (Chair: Candice Klug, Medical College of Wisconsin)New Insights into the Structure and Dynamics of the Ca2+ Binding Domain of the Cardiac Na+/Ca2+ Exchanger Determined by Site Directed Spin Labeling (Al Beth, Vanderbilt University)11:05amAll in the Arms of EcoRI: Clues into Protein-DNA Specificity Determinants by Pulsed ESR Distance Measurements (Sunil Saxena, University of Pittsburgh)11:25amSpin Label Geometries and Protein Flexibility from DEER constraints (Christian Altenbach, UCLA)11:45pmRevealing Conformational Exchange in Spin Labeled Proteins (Wayne Hubbell, UCLA)12:05pmDiscussion12:15pmGroup Photo12:45pmLunch 1:30pmIn Vivo EPR Spectroscopy and Imaging - Dedicated to Ted Walczak (Chair: Harold Swartz, Dartmouth Medical School) 1:35pmEPR as a Noninvasive Tool to Study the Tumor Micro-environment (Bernard Gallez, Universite Catholique de Louvain, Brussels, Belgium)1:55pmEPR in the Field of Drug Delivery (Karsten Mader, Martin-Luther-University of Halle)2:15pmEPR-guided Oxygen Therapy in Ischemic Stroke (Ke Jian Jim Liu, University of New Mexico, Albuquerque)2:35pmOxygen-guided Optimization of Radiotherapeutic Efficacy for Gliomas using Multi-site EPR Oximetry (Nadeem Khan, Dartmouth Medical School)2:55pmDiscussion3:05pmBreak and Poster Viewing3:35pmEPR Imaging of Oxygen (Howard Halpern, University of Chicago)3:55pmClinical EPR: Challenges and Progress (Harold Swartz, Dartmouth Medical School)4:15pmInnovative Resonators for EPR/ֱapp Co-imaging (Jay Zweier, Davis Heart & Lung Research Institute)4:45pmDiscussion4:55pm__________________________ Short Oral Communications (Chair: TBD) ____________________ (_______)5:10pm____________________ (_______)5:25pm____________________ (_______)5:40pm____________________ (_______)5:55pmPoster Viewing and Cash Bar9:30pmAdjourn  THURSDAY, MAY 67:30amContinental Breakfast and Poster Viewing8:00amEPR Simulations (Chair: Sushil Misra, Concordia University, Quebec, Canada)Simulation of Slow-motion CW EPR Spectrum using Stochastic Liouville Equation for an Electron Spin Coupled to Two Nuclei with Arbitrary Spins (Sushil Misra, Concordia University, Quebec, Canada)8:20amRapid Development of EPR Resonators using Finite-Element Modeling (Jason Sidabras, Medical College of Wisconsin)8:40amEvolution of Spectral Interpretation From Spin Systems to Molecular Structure and Beyond (Graeme Hanson, University of Queensland, Brisbane, Australia)9:00amDiscussion9:10amSpin Traps and Nitroxides in Translational Research (Chair: Marcos Lopez, Medical College of Wisconsin) Observations on the Biomedical Therapeutic Potential of PBN-Nitrones (Robert Floyd, Oklahoma Medical Research Foundation)9:30amUse of Nitroxide Antioxidants in Cancer Treatment and Prevention (James Mitchell, NCI)9:50amMitochondria-targeted Agents in Breast Cancer Detection and Therapy (Marcos Lopez, Medical College of Wisconsin)10:10amDiscussion10:20amBreak and Poster Viewing10:50amEPR Dosimetry (Chair: Harold Swartz, Dartmouth Medical School)Overview and Progress towards Field Deployment (Benjamin Williams, Dartmouth Medical School)11:10amIncorporation of EPR Dosimetry into the Emergency Response System (Ann Flood, Dartmouth Medical School and R. Javier Nicolalde, Dartmouth Medical School )11:30amDevelopment of Resonators for In Vivo EPR Imaging (Hiroshi Hirata, Hokkaido University, Sapporo, Japan)11:50amEPR Dosimetry Based on Fingernail Clippings (Steven Swarts, University of Rochester, New York)12:10pmDiscussion12:20pmClosing Remarks (Lawrence Berliner, University of Denver)12:35pmAdjourn SUNDAY, MAY 22:00pmRegistration3:00- 6:00pmCore-to-Core Sympsium (Organized by: Periannan Kuppusamy, Ohio State University and Hideo Utsumi, Kyushu University, Fukuoka, Japan) 7:00pmWelcome Reception &'/R~~qdTdTI1/jhgdB*CJUaJmHnHphtHuhYqhRuCJaJh@^hPf5CJOJQJaJhgd5CJOJQJaJhA[5CJOJQJaJhYqhPf5CJ OJQJaJ hYqhYq5CJ OJQJaJ &h8\LhYq59@CJOJQJaJh@^5@CJOJQJaJ(h8\LhYq5B*CJOJQJaJph(h8\Lh8\L5B*CJOJQJaJph(jhRhRCJUaJmHnHuC } ~ $d$Ifa$gd.K d8gdL$ dgdPf $da$gdYq   | } ~ к}hRhRhGC2 hlhBB5B*CJ aJ phhBBhyhBBCJaJ+hyhBB5B*CJH*OJQJaJph(hyhBB5B*CJOJQJaJphhPfhnVB*CJaJphhnVB*CJaJphhPfB*CJaJph+jhRB*CJUaJmHnHphu+jh B*CJUaJmHnHphu1jhRhR@MB*CJUaJmHnHphu+jhNK/B*CJUaJmHnHphu ugdt$Ifgd.K$d$Ifa$gd.Kxkd$$Ifl+  t P0 44 lap Pyt.K  ! b d e   V X Y `   : ; < = Źvkh?hBBCJ aJ hlhBB6B*CJ aJ phh2CJ aJ h2h26CJ aJ hlhBBCJ PJ^JaJ hlhBBB*CJ aJ phhlhBB6CJ aJ hlhBB6B*CJ aJ phh3hBB6CJ aJ hlhBB5CJ aJ h.KhBBhlhBBCJ aJ * dSEdt$Ifgd.K$d$Ifa$gd.Kkd$$Ifl04   t02 44 lapyt.K ! 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