If you have developed processes to prepare an API, you have certainly come across a number of catalytic reactions using transition metals, and you will have noticed that they can be challenging to reproduce. Have you seen cases in which a reaction was run a dozen time successfully in the lab but failed in the plant? If so, you are not alone. What makes these reactions so difficult to scale-up is that the catalysts are unstable and their presence cannot be monitored by the traditional methods, at least if the catalyst is used in very small amounts, which is always the case in a practical catalytic reaction. Therefore, one must resort to some level of kinetic analysis.
The course will go through the most basic situations in which simple kinetic analysis can identify the rate-determining step, the resting state of the catalyst, possible promoters or inhibitors of the reaction (including adventitious impurities like oxygen and water), and whether the catalyst decomposes appreciably. Are there off-cycle species depleting the catalytic cycle and slowing down the reaction appreciably? These notions are rather simple and do not require complex math but are not trivial.
This is information you will need in order to scale the optimized reaction with confidence:
In addition to ensuring robustness, kinetic analysis will help you optimize reactions when the results are not acceptable. Do you wish to reduce a side-product formation? Do you wish to prevent a decomposition reaction? Improve catalyst stability? Operate at lower temperature? Kinetic studies will help you address all these situations.
The course will include a presentation of case studies, taken both from the published literature and the tutor’s personal experience. These case studies will illustrate a number of ways in which a catalytic reaction can go wrong and how problems can be resolved. Finally, you will have the opportunity to apply your newly acquired knowledge to a series of problems in an open-discussion format.
We are delighted to provide this online course, it will be divided up into four sessions using an online platform. Dates and times are as follows and set in UK, BST (British Summer Time):
Monday, October 20 | 2.00 – 5.00pm BST
Tuesday, October 21 | 2.00 – 5.00pm BST
Monday, October 27 | 2.00 – 5.00pm BST
Tuesday, October 28 | 2.00 – 5.00pm BST
The course will go through the most basic situations in which simple kinetic analysis can identify the rate-determining step, the resting state of the catalyst, possible promoters or inhibitors of the reaction (including adventitious impurities like oxygen and water), and whether the catalyst decomposes appreciably. Are there off-cycle species depleting the catalytic cycle and slowing down the reaction appreciably? These notions are rather simple and do not require complex math but are not trivial.
This is information you will need in order to scale the optimized reaction with confidence:
In addition to ensuring robustness, kinetic analysis will help you optimize reactions when the results are not acceptable. Do you wish to reduce a side-product formation? Do you wish to prevent a decomposition reaction? Improve catalyst stability? Operate at lower temperature? Kinetic studies will help you address all these situations.
The course will include a presentation of case studies, taken both from the published literature and the tutor’s personal experience. These case studies will illustrate a number of ways in which a catalytic reaction can go wrong and how problems can be resolved. Finally, you will have the opportunity to apply your newly acquired knowledge to a series of problems in an open-discussion format.
We are delighted to provide this online course, it will be divided up into four sessions using an online platform. Dates and times are as follows and set in UK, BST (British Summer Time):
Monday, October 20 | 2.00 – 5.00pm BST
Tuesday, October 21 | 2.00 – 5.00pm BST
Monday, October 27 | 2.00 – 5.00pm BST
Tuesday, October 28 | 2.00 – 5.00pm BST
