Our Organ Modelling Congress addresses an important and expanding field which provides new understandings in organ functionality and novel approaches to drug development. These engineered human organs using Organ-on-a-Chip, Tissue-on-a-Chip & Organoids are a remarkable tool with the potential to facilitate studies that better predict drug efficacy and thereby reduce cost, time, and failure rates in clinical trials. Further, patient-derived organoids hold promise for personalised medicine, as they have the potential to produce individualised predictions of drug response.